解剖学报

›› 2012, Vol. 43 ›› Issue (4): 518-523.doi: 10.3969/j.issn.0529-1356.2012.04.014

• 组织学胚胎学发育生物学 • 上一篇    下一篇

孕期酒精暴露对子鼠视网膜双极细胞和水平细胞发育的影响

刘曦1,2; 王永毅2; 姚焕玲1; 赵博2; 于亚东2; 胡馨2; 邓锦波1*   

  1. 1.河南大学神经生物学研究所，河南 开封 475004; 2.河南大学淮河医院眼科，河南 开封 475000
  • 收稿日期:2011-05-16 修回日期:2012-02-03 出版日期:2012-08-06
  • 通讯作者: 邓锦波

Prenatal alcohol exposure affects development of retinal bipolar and horizontal cells in mice

  1. 1.Institute of Neurobiology, He’nan University, He’nan Kaifeng 475004, China; BR>2.Department of Ophthalmology, Huaihe Hospital of He’nan University, He’nan Kaifeng 475000,China BR>
  • Received:2011-05-16 Revised:2012-02-03 Online:2012-08-06
  • Contact: DENG Jin-bo

关键词: 胎儿酒精综合症, 视网膜, 双极细胞, 水平细胞, 免疫荧光, DiI散射, 小鼠

Abstract: Objective To investigate effects of alcohol exposure during pregnancy on retinal bipolar and horizontal cells in filial mice.Methods The animal model of prenatal alcohol exposure was made. The development of bipolar cells and horizontal cells at prenatal days 7, 14 and 30 was investigated with immunofluorescent labeling and DiI scattering techniques. Results In all age groups, the density of the bipolar cells was significantly lower in the experiment groups than in the control groups. The dendritic field and the number of branches of horizontal cells were significantly lower in the experimental group than in the control group ( P <0.01). Conclusion Alcohol exposure during pregnancy affects development of retinal bipolar and horizontal cells in mice.

Key words: Fetal alcohol syndrome, Retina, Bipolar cell, Horizontal cell, Immunofluorescence, DiI diotistic, Mouse

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